Marmite has traditionally been eaten as a savoury spread on bread, toast, savoury biscuits or crackers, and other similar baked products. Owing to its concentrated taste, it is often spread very thinly in combination with butter or margarine. It can be made into a savoury hot drink by adding one teaspoon to a mug of hot water, much like Oxo or Bovril. It is also commonly used to enrich casseroles and stews.

Marmite is often paired with cheese – for example, in a cheese sandwich or a cheese-flavoured biscuit such as Mini Cheddars. In the UK, Starbucks offers a cheese and Marmite panini. There are Marmite-flavoured varieties of Walkers Crisps, and of some brands of rice cakes and biscuits.

Marmite has also been used as an ingredient in cocktails, including the Marmite Cocktail and the Marmite Gold Rush.

Celebrity chefs have created signature Marmite-flavoured recipes: Nigella Lawson has one for Marmite spaghetti, and Heston Blumenthal has one for Marmite consommé.